Publications



  • Pierpont, T.M., Lyndaker, A.M.§, Anderson, C.M., Jin, Q., Moore, E.S., Roden, J.L., Braxton, A., Bagepalli, L., Kataria, N., Hu, H.Z., Garness, J., Cook, M.S., Capel, B., Schlafer, D.H., Southard, T., and Weiss R.S.§ (2017) Chemotherapy-induced depletion of OCT4-positive cancer stem cells in a mouse model of malignant testicular cancer. Cell Reports 21:1896–1909. (§co-corresponding authors). Pubmed

  • Apoorva, F., Tian, Y., Pierpont, T.M., Bassen, D., Butcher, J., Weiss, R.S., and Singh, A. (2017) Lymph Node Stiffness Mimicking Hydrogels Regulate Human B Cell Lymphoma Growth and Cell Surface Receptor Expression in a Molecular Subtype-Specific Manner. Journal of Biomedical Materials Research: Part A. 105:1833-1844. Pubmed

  • Liu, Y., Cussiol, J.R., Dibitetto, D., Sims, J.R., Twayana, S., Weiss, R.S., Freire, R., Marini, F., Pellicioli, A., and Smolka, M.B. (2017) TOPBP1/Dpb11 Plays a Conserved Role in Homologous Recombination DNA Repair Through the Coordinated Recruitment of 53BP1/Rad9 J. Cell Biol. 216:623-639. Pubmed

  • Bordeleau, F., Mason, B.N., Lollis, E., Mazzola, M.C., Zanotelli, M.R., Somasegar, S., Califano, J.P., Montague, C.R., LaValley, D., Huynh, J., Mencia-Trinchant, N., Abril, Y.L.N., Hassane, D.C., Bonassar, L.J., Butcher, J.T., Weiss, R.S., and Reinhart-King, C.A. (2017) Matrix stiffening promotes a tumor vasculature phenotype. Proceedings of the National Academy of Science USA, 114:492-497. Pubmed

  • Subbaramaiah, K., Brown, K.A., Zahid, H., Balmus, G., Weiss, R.S., Herbert, B.-S., and Dannenberg, A.J. (2016) Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells. J. Biol. Chem. 291:16011-16023. Pubmed

  • Wisitpitthaya, S., Zhao,Y., Long, M.J.C., Li, M., Fletcher, E.A., Blessing, W.A., Weiss, R.S., and Aye, Y. (2016) Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition. ACS Chemical Biology, 11:2021-2032. Pubmed

  • Jing, H., Hu, J., He, B., Abril, Y.L.N., Stupinski, J., Weiser, K., Carbonaro, M., Chiang,Y-L., Southard, T., Giannakakou, P., Weiss, R.S., and Lin, H. (2016) A SIRT2-selective inhibitor promotes c-Myc oncoprotein degradation and exhibits broad anticancer activity. Cancer Cell 29:297–310. Pubmed

  • Sadhukhan, S., Liu, X., Ryu, D., Nelson, O.D., Stupinski, J.A., Li,Z., Chen,W., Zhang, S., Weiss, R.S., Locasale, J.W., Auwerx, J., and Lin, H. (2016) Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of heart function. Proceedings of the National Academy of Science USA 113:4320-4325. Pubmed

  • Bordeleau, F., Califano, J.P., Abril, Y.L.N., Mason, B.N., LaValley, D., Bonassar, L.J., Shin, S.J., Weiss, R.S., and Reinhart-King, C.A. (2015) Tissue stiffness regulates serine/arginine rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors. Proceedings of the National Academy of Science USA 112:8314-8319. Pubmed

  • Lim, P.X., Patel, D.R., Poisson, K.E., Basuita, M., Tsai, C., Lyndaker, A.M., Hwang, B.-J., Lu, A-L., and Weiss, R.S. (2015) Genome protection by the 911 subunit HUS1 requires clamp formation, DNA contacts, and ATR signaling-independent effector functions. J. Biol. Chem. 290:14826-14840. Pubmed

  • Balmus G., Lim, P.X., Oswald A., Hume K.R., Cassano A., Pierre J., Hill A., Huang W., August A., Stokol T., Southard T., and Weiss R.S. (2016) HUS1 regulates in vivo responses to genotoxic chemotherapies. Oncogene 35(5):662-669. Pubmed

  • Aye, Y. Li, M., Long, M.J.C., and Weiss, R.S. (2015) Ribonucleotide Reductase and cancer: biological mechanisms and targeted therapies. Oncogene 34:2011-2021. Pubmed

  • Okayama, S., Kopelovich, L., Balmus, G., Weiss, R.S., Herbert, B.-S., Dannenberg, A.J., and Subbaramaiah, K. (2014) p53 Regulates Wnt Signaling Via Effects on Aha1 and Hsp90. J. Biol. Chem. 289:6513-6525. Pubmed

  • Li, M., Jirapatnakul, A., Biancardi, A., Riccio, M.L., Weiss, R.S., and Reeves, A.P. (2013) Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images. PLoS ONE 8(12): e83806. doi:10.1371/journal.pone.0083806. Pubmed

  • Yu, J., Sadhukhan, S., Noriega, L.G., Moullan, N., He, B., Weiss, R.S., Lin, H., Schoonjans, K., and Auwerx, J. (2013) Metabolic Characterization of a Sirt5 deficient mouse model. Scientific Reports 3:2806. Pubmed

  • Lyndaker, A.M., Vasileva, A., Wolgemuth, D.J., Weiss, R.S., and Lieberman, H.B. (2013) Clamping down on mammalian meiosis. Cell Cycle 12(19):3135-45 Pubmed

  • Ouzounov, D.G., Rivera, D.R., Williams, W.O., Stupinski, J.A., Southard, T.L., Hume, K.R., Brown, C.M., Weiss, R.S., Webb, W.W., and Xu, C. (2013) Dual modality imaging of unstained tissues with an endomicroscope with optical zoom capability. Biomedical Optics Express 4:1494–1503. Pubmed

  • Nowakowski, S.G, Kolwicz, S.C. Jr., Korte, F.S., Luo, C., Robinson-Hamm, J.N., Page, J.L., Brozovich, F.V., Weiss, R.S., Tian, R., Murry, C.E., and Regnier, M. (2013) Transgenic overexpression of Ribonucleotide Reductase improves cardiac performance. Proceedings of the National Academy of Science USA 110:6187-6192. PubMed

  • Lyndaker, A.M., Lim, P.X., Mleczko, J.M., Diggins, C., Holloway, J.K., Holmes, R.J., Kan, R., Schlafer, D.H., Freire, R., Cohen, P.E., and Weiss, R.S. (2013) Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. PLoS Genet. 9(2): e1003320. doi:10.1371/journal.pgen.1003320. PubMed

  • Stover, P.J. and Weiss, R.S. (2012) Sensitizing cancer cells: Is it really all about U? Cancer Cell 22:3-4. PubMed

  • Balmus, G., Zhu, M., Mukherjee, S., Lyndaker, A.M., Hume, K.R., Lee, J., Riccio, M.L., Reeves, A.P., Sutter, N.B., Noden, D.M., Peters, R.M., and Weiss, R.S. (2012) Disease severity in a mouse model of Ataxia Telangiectasia is modulated by the DNA damage checkpoint gene Hus1. Human Molecular Genetics 21:3408–3420 (featured on journal cover shown at right). PubMed

  • Daugherity, E.K., Balmus, G., Al Saei, A., Moore, E.S., Abi Abdallah, D., Rogers, A.B., Weiss, R.S., and Maurer, K.J. (2012) The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle 11:1918-1928. PubMed

  • Qi, Q., Huang, W., Bai, Y., Balmus, G., Weiss, R.S. and August, A. (2012) A unique role for ITK in survival of invariant NKT cells associated with the p53 dependent pathway in mice. Journal of Immunology 188:3611-3619. PubMed

  • Pavlova, I.P., Hume, K.R., Yazinski, S.A., Flanders, J., Southard, T.L., Weiss, R.S. and Webb, W.W. (2012) Multiphoton microscopy and microspectroscopy for diagnostics of inflammatory and neoplastic lung. Journal of Biomedical Optics 17, 036014 (2012), DOI:10.1117/1.JBO.17.3.036014. PubMed

  • Jinadasa R.N., Bloom, S.E., Weiss, R.S., and Duhamel, G.E. (2011) Cytolethal Distending Toxin: A conserved bacterial genotoxin that blocks cell cycle progression leading to apoptosis of a broad range of mammalian cell lineages. Microbiology 157: 1851-1875. PubMed

  • Holloway, J.K., Mohan, S., Balmus, G., Sun, X., Modzelewski, A., Borst, P.L., Freire, R., Weiss, R.S., and Cohen, P.E. (2011) Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. PLoS Genet. 7(6): e1002094. doi:10.1371/journal.pgen.1002094. PubMed

  • Jinadasa R., Balmus, G., Gerwitz, L., Roden, J., Weiss, R., and Duhamel, G. (2011) Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice. http:// www.jove.com/details.stp?id=2598 doi: 10.3791/2598. J. Vis. Exp. 50. PubMed

  • Selvaraj, V., Asano, A., Page, J., Nelson, J.L., Kumar, K., Foster, J., Brenna, T., Weiss, R.S. and Travis, A.J. (2010). Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile. Dev. Biol. 348: 177-189. PubMed

  • Ylikallio, E., Page, J.L., Xu, X., Lampinen, M., Bepler, G., Ide, T., Tyynismaa, H., Weiss, R.S. and Suomalainen, A. (2010). Ribonucleotide Reductase is not limiting for mitochondrial DNA copy number in mice. Nucleic Acids Res. 38: 8208-8218. PubMed

  • Song, I.Y., Barkley, L.R., Day, T.A., Weiss, R.S., and Vaziri, C. (2010) A novel role for Fanconi Anemia (FA) pathway effector protein FANCD2 in cell cycle progression of untransformed primary human cells. Cell Cycle 9: 2375-2388. PubMed

  • Pavlova, I.P., Hume, K.R., Yazinski, S.A., Peters, R.M., Weiss, R.S. and Webb, W.W. (2010) Multiphoton microscopy as a diagnostic imaging modality for lung cancer, Proceedings of the Society of Photo-Optical Instrumentation Engineers, Vol. 7569, 756918. PubMed

  • Yazinski, S.A., Westcott, P.M., Ong, K., Pinkas, J., Peters, R.M., and Weiss, R.S. (2009) Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration. Proceedings of the National Academy of Science USA 106: 21282–21287. PubMed
    Cornell news release

  • Selvaraj, V., Asano, A., Buttke, D.E., Sengupta, P., Weiss, R.S., and Travis, A.J. (2009) Mechanisms underlying the micron-scale segregation of sterols and GM1 in live mammalian sperm. J. Cell. Physiol. 218: 522–536. PubMed

  • Meyerkord, C.L., Takahashi, Y., Araya, R., Takada, N., Weiss, R.S., and Wang, H- G. (2008) Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins. Oncogene 27: 7248–7259. PubMed

  • Xu, X., Page, J.L., Surtees, J.A., Liu, H., Lagedrost, S., Lu, Y., Bronson, R., Alani, E., Nikitin, A. Yu., and Weiss, R.S. (2008) Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. Cancer Res. 68: 2652-2660. PubMed

  • Francia, S., Weiss, R.S., and d'Adda di Fagagna, F. (2007) Need telomere maintenance? Call 911. Cell Division 2: 3. PubMed

  • Levitt, P.S., Zhu, M., Cassano, A., Yazinski, S.A., Liu, H., Darfler, J., Peters, R.M., and Weiss, R.S. (2007) Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1. Mol. Cell. Biol. 27: 2189-2201. PubMed

  • Zhu, M. and Weiss, R.S. (2007) Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells. Mol. Biol. Cell 18: 1044-1055. PubMed

  • Francia, S., Weiss, R.S., Hande, M.P., Freire, R., and d'Adda di Fagagna, F. (2006) Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex. Curr. Biol. 16: 1551-1558. PubMed

  • Berghorn, K.A., Clark-Campbell, P.A., Han, L., McGrattan, M., Weiss, R.S., and Roberson, M.S. (2006) Smad6 represses Dlx3 transcriptional activity through inhibition of DNA binding. J. Biol. Chem. 281: 20357-20367. PubMed

  • Affar, E.B., Luke, M.P., Gay, F., Calvo, D., Sui, G., Weiss, R.S., Li, E., and Shi, Y. (2006) Targeted ablation of Par-4 reveals a cell-type specific susceptibility to apoptosis-inducing agents. Cancer Res. 66:3456-3462. PubMed

  • Wang, X., Hu, B., Weiss, R.S., and Wang, Y. (2006) The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of non-homologous end-joining. Oncogene 25: 1980-1983. PubMed

  • Levitt, P.S., Liu ,H., Manning, C., and Weiss, R.S. (2005) Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene. Genomics 86:212-224. PubMed

  • Wang, X., Guan, J., Hu, B., Weiss, R.S., Iliakis, G., and Wang, Y. (2004) Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation. Nucleic Acids Res. 32: 767-775. PubMed



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